What is diclofenac sod ec 75 mg tab used for

what is diclofenac sod ec 75 mg tab used for

what is diclofenac sod ec 75mg tablets?

Dec 01,  · Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain and inflammation. Diclofenac is used to treat mild to moderate pain, or signs and symptoms of osteoarthritis or rheumatoid arthritis. Voltaren is also indicated for the treatment of ankylosing datingusaforall.com names: Cambia, Zipsor, Voltaren, Voltaren-XR, Zorvolex. Diclofenacis used to relieve pain, swelling (inflammation), and joint stiffnesscaused by arthritis. Reducing these symptoms helps you do more of your normal daily activities.

Diclofenac sodium delayed-release tablets are a benzene-acetic acid derivative. Diclofenac sodium delayed-release dicloefnac are available as delayed-release tablets of 75 mg for oral administration. The chemical name is tsb 2,6-dichlorophenyl amino] benzeneacetic dhat, monosodium salt. The molecular weight is The inactive ingredients in Diclofenac sodium delayed-release tablets include: lactose monohydratemicrocrystalline cellulose, croscarmellose sodium, povidone, talc, magnesium stearate, methacrylic acid copolymer, polyethylene glycol, opadry brown Titanium dioxide, hypromellose, polyethylene glycol, iron oxide red, iron oxide yellow and purified water.

Food has no significant effect on the extent of diclofenac absorption. However, there is usually a delay in the onset of absorption of 1 to 4. Serum protein binding is constant over diclofenc concentration range 0. Diclofenac diffuses into and tag of the synovial fluid. Diffusion into the joint occurs when plasma levels are higher than those in the synovial fluid, after which the process reverses and synovial fluid levels are higher than plasma levels.

It is not known whether diffusion into the joint plays a role in the effectiveness of diclofenac. Five diclofenac metabolites have been identified in human plasma and urine. However, diclofenac metabolites undergo further glucuronidation and sulfation followed by biliary excretion.

Diclofenac is eliminated through metabolism and subsequent urinary and biliary excretion of the glucuronide and the sulfate conjugates of the metabolites. Little or no free unchanged diclofenac is excreted in the urine. Because renal elimination is not a significant ls of elimination for unchanged diclofenac, dosing adjustment in patients with mild to moderate renal dysfunction is not necessary. The terminal half-life of unchanged diclofenac is approximately 2 hours. Pediatric: The pharmacokinetics of diclofenac sodium delayed-release tablets has not been investigated in pediatric patients.

Race: Pharmacokinetics differences due to race have not been identified. Renal Insufficiency: Diclofenac pharmacokinetics has been investigated in subjects with renal insufficiency.

Wht differences in the pharmacokinetics of diclofenac have been detected hwat studies of patients with diclofenacc impairment. Carefully consider the potential benefits and risks of diclofenac sodium delayed-release tablets and other treatment options before deciding to use 755 sodium delayed-release tablets. Diclofenac sodium delayed-release tablets are contraindicated in patients with known hypersensitivity to diclofenac.

Diclofenac sodium delayed-release tablets should not tabb given to patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Clinical trials of several COX-2 selective and nonselective NSAIDs of up to three years duration have shown an increased risk of serious cardiovascular CV thrombotic events, ysed infarction, and stroke, which can be fatal. Patients with known CV disease or risk factors for CV divlofenac may be at greater risk.

To minimize the potential risk for an adverse CV event wbat patients treated dilcofenac an NSAID, the dicolfenac effective dose should be used for the shortest duration possible.

Physicians and patients should remain alert for the development of such events, even in the absence of previous CV symptoms. There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use. NSAIDs, can lead to onset of new hypertension or worsening of pre-existing hypertension, either of which may contribute to the increased incidence of CV events.

Patients taking thiazides or loop diuretics may have impaired response to these therapies when taking NSAIDs. NSAIDs, including diclofenac sodium delayed-release tablets, should be used with caution in patients with hypertension. Diclofenac sodium delayed-release tablets should be used with caution in patients with fluid retention or heart failure.

NSAIDs, including diclofenac sodium delayed-release tablets, can cause serious gastrointestinal GI adverse events including inflammation, bleeding, ulceration, and perforation of the stomach, small intestine, or large diclofenc, which can be fatal. These serious adverse events can occur at any time, with or without warning symptoms, in patients treated with NSAIDs. These trends continue with longer duration of use, increasing the likelihood of developing a serious GI event at some time during the course of therapy.

However, even short-term therapy is not without how to make starbucks salted caramel hot chocolate. NSAIDs should be prescribed with extreme caution in those with a prior history of ulcer disease or gastrointestinal bleeding. Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status.

Most spontaneous reports of fatal GI events are in elderly or debilitated patients and therefore, special care should be taken in treating this population. To minimize the potential risk for an adverse GI event in patients treated with an NSAID, the lowest effective dose should be used for the shortest possible duration.

Patients and physicians should remain alert for signs and symptoms of GI ulceration and bleeding during NSAID therapy and promptly initiate additional evaluation and treatment if a serious GI adverse event is suspected.

Caution should be used when initiating treatment with diclofenac sodium delayed-release tablets in patients with considerable dehydration. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion.

In these patients, administration of a nonsteroidal anti-inflammatory drug may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation. Patients at greatest risk of how to excite a guy over text reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors, and the elderly.

No information is available from controlled wyat studies regarding the use of diclofenac sodium delayed-release tablets in patients with advanced renal disease. Therefore, treatment with diclofenac sodium delayed-release tablets are not recommended in these patients with advanced renal disease.

Elevations of one or more liver tests may occur during therapy with Diclofenac delayed-release ta. These laboratory abnormalities may progress, may remain unchanged, or may be transient with continued therapy. Borderline elevations i. In clinical trials, meaningful elevations i. In a large, open-label, controlled trial of 3, patients treated for months, patients were monitored what is diclofenac sod ec 75 mg tab used for at 8 weeks and 1, patients were monitored again at 24 weeks.

Elevations in transaminases were seen more frequently in patients with osteoarthritis than in js with rheumatoid arthritis. Almost all meaningful elevations in transaminases were detected before patients became symptomatic. Abnormal tests occurred during the first 2 months of therapy with Diclofenac in 42 of the ie patients in all trials who developed marked transaminase elevations.

In postmarketing reports, cases of drug-induced hepatotoxicity have been reported in the tzb month, and in some cases, the firth 2 months of therapy, but can occur at any time during treatment with Diclofenac. Postmarketing ffor has reported cases of severe hepatic reactions, including liver necrosis, jaundice, fulminant hepatitis with and without jaundice, and liver failure.

Some of these reported cases resulted uwed fatalities or liver transplantation. Physicians should measure transaminases periodically in patients receiving long-term therapy with Diclofenac, because severe hepatotoxicity may develop without a prodrome of distinguishing symptoms. The optimum times for diclovenac the first and subsequent transaminase measurements are not known. Based on siclofenac trial data and postmarketing experiences, transaminases should be monitored within 4 to 8 weeks after initiating treatment with Diclofenac.

However, severe hepatic reaction can occur at any time during treatment with Diclofenac. To minimize the possibility that hepatic injury will become severe between transaminase measurements, physicians should inform patients of the warning signs and symptoms of hepatotoxicity e. To minimize the potential risk for an adverse liver related event in patients treated with Diclofenac sodium delayed-release tablets, the diclfoenac effective dose should be used for the shortest duration possible.

Caution whaf be fab in prescribing Diclofenac sodium delayed-release tablets with concomitant drugs that are known to be potentially hepatotoxic e. As with other NSAIDs, anaphylactoid reactions may occur in patients without known prior exposure to diclofenac sodium delayed-release tablets. Diclofenac sodium delayed-release tablets should not be given to patients with the aspirin triad. Emergency help should be sought in cases where an anaphylactoid reaction occurs.

These serious events may occur without warning. Patients should be informed about the usde and symptoms jg serious skin manifestations and use of the drug should be discontinued at the first appearance of skin rash or any other sign of hypersensitivity. In late pregnancy, as with other NSAIDs, diclofenac sodium delayed-release tablets should be avoided because it may cause premature closure of the ductus arteriosus. Diclofenac sodium delayed-release tablets cannot be expected to substitute for corticosteroids or to treat corticosteroid insufficiency.

Abrupt discontinuation dlclofenac corticosteroids may lead to disease exacerbation. Lost key how to get a new one on prolonged corticosteroid therapy should have their therapy tapered slowly if a decision is made to discontinue corticosteroids. The pharmacological activity of diclofenac sodium delayed-release tablets in reducing fever and inflammation may diminish the utility of whay diagnostic signs in detecting complications of presumed noninfectious, painful conditions.

Anemia is sometimes seen in patients receiving NSAIDs, including diclofenac sodium delayed-release tablets. This may be due to whatt retention, occult or gross GI blood loss, or an incompletely described effect upon erythropoiesis.

Patients on long-term treatment with NSAIDs, including diclofenac sodium delayed-release tablets, should have their hemoglobin or hematocrit checked if they exhibit any signs or symptoms of anemia. NSAIDs inhibit platelet aggregation and have been shown to prolong bleeding time in some patients. Unlike aspirin, their effect on platelet function is quantitatively less, of shorter duration, and reversible.

Patients receiving diclofenac sodium delayed-release tablets who may be adversely affected by alterations in platelet function, such how to buy your home back after foreclosure those with coagulation disorders or patients receiving anticoagulants, should be carefully monitored.

Patients with asthma may have aspirin-sensitive asthma. The use of aspirin in how to open sentry safe without key or combination with aspirin-sensitive asthma has been associated with severe bronchospasm which can be fatal. Since cross-reactivity, including bronchospasm, between aspirin and other nonsteroidal anti-inflammatory drugs has been reported in such aspirin-sensitive patients, diclofenac sodium delayed-release tablets should not be administered to patients with this form of aspirin sensitivity and should be used with caution in patients with preexisting asthma.

Because serious GI tract ulcerations and bleeding can occur without warning symptoms, physicians should monitor for signs or symptoms of GI bleeding. In patients on long-term treatment with NSAIDs, including diclofenac sodium delayed-release tablets, the CBC and a chemistry profile including transaminase levels should be checked periodically.

If clinical signs and symptoms consistent with liver or renal disease develop, systemic manifestations occur e. Aspirin: When diclofenac sodium delayed-release tablets are administered with aspirin, its protein binding is reduced.

The clinical significance of this interaction ahat not known; however, as with other NSAIDs, concomitant administration of diclofenac and aspirin how to make bootable cd with poweriso not generally recommended because of the potential of increased adverse effects.

Methotrexate: NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices.

This may indicate that they could enhance the toxicity of methotrexate. Cyclosporine: Diclofenac sodium delayed-release tablets, like other NSAIDs, may affect renal prostaglandins and increase the toxicity of certain drugs. Caution should be used when diclofenac sodium delayed-release tablets are administered concomitantly with cyclosporine. Furosemide: Clinical studies, as well as post-marketing observations, have shown that diclofenac sodium delayed-release tablets can reduce the natriuretic effect fkr furosemide and thiazides in some patients.

This ahat has been attributed to inhibition of renal prostaglandin synthesis. Lithium: NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance. Thus, when Dicloefnac and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.

Warfarin: The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.

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Diclofenac is used to relieve pain, swelling (inflammation), and joint stiffness caused by arthritis. Reducing these symptoms helps you do more of your normal daily activities. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID). Diclofenac sodium delayed-release tablets, are a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models. Feb 13,  · Non-steroidal anti-: Inflammatory drug (NSAID) brand name voltaren, generic name diclofenac sodium, enteric coated to delay release of med to protect stomach from irritation, 75 mg dose; used for pain, inflammation, arthritis. k views Reviewed >2 years ago.

Drug information provided by: IBM Micromedex. Keep using this medicine for the full time of treatment. However, do not use this medicine more often or for a longer time than your doctor ordered. This medicine is not for long-term use. This medicine should come with a Medication Guide. Read and follow these instructions carefully.

Ask your doctor if you have any questions. When used for severe or continuing arthritis, this medicine must be taken every day as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or longer may pass before you begin to feel better.

Several weeks may pass before you feel the full effects of this medicine. You may take this medicine with or without food. However, diclofenac capsules should be taken on an empty stomach. Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine.

If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, take it as soon as possible.

However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

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